For Captain Paget and her platoon of Colonial Marines, a routine mission for the Weyland-Yutani Corporation becomes a running battle that will carry them halfway across the galaxy in a fateful four-way war. It begins with a deadly encounter with a tribe of the interstellar hunters know as the Predators, but quickly devolves into a battle for survival against the three deadliest species in the galaxy, as the Colonial Marines end up on a horror collision course with an army of Aliens and the god-like Engineers from Prometheus.