This book grapples with complex contemporary politics of knowledge from a decolonial epistemic perspective and gestures towards constructions of pluriversal knowledges amenable to pluriversal worlds. It begins with the long story of how the global architecture of knowledge came to be Eurocentric, why these matters for our time, and what the principal currents of decolonial scholarship have brought to the conversation. At its heart is the idea of knowledge as life which subverts the dominant Western conception of knowledge as power, as something to be extracted, commodified, and wielded. Theoretically, it boldly develops decolonial systematic conceptual architecture of knowledge. Empirically, it engages contemporary debates on the African university, the Rhodes Must Fall movements, language and literature, restitution of cultural heritage, and the global stakes of African epistemic freedom while widening the lens to the planetary scale of reworlding the world into its pluriverses.