Big name creators take on the world of Spider-Man, including the wall-crawler debut of Spidey artist legend John Romita Jr.! In this Epic Collection, Dennis O'Neil and John Romita Jr. make their Amazing Spider-Man debuts and bring with them the first appearance of Madame Web! New York City has always been a defining element in Spider-Man's world, and, like many a New Yorker, the city's going to drive him crazy - if it doesn't kill him first. From an New York Marathon assassination plot to Peter Parker's paper-thin apartment walls; from a merged Hydro-Man/Sandman to running into your ex-girlfriend's new beau Biff Rifkin, the City That Never Sleeps just won't give Spidey a break. And the knocks keep coming when Peter Parker is accused of causing a prison break. Also featuring the Aunt May solo 'adventure' you demanded and two iconic Dennis O'Neil/Frank Miller Annuals co-starring Doctor Strange and the Punisher! Collecting: Amazing Spider-Man (1963) #207-223 & Annual (1964) #14-15