Kanzaki Shizuku is the son of a recently deceased, world-renowned wine critic, Kanzaki Yutaka, who owns a vast wine collection. In order to take ownership of his legacy, he must find 13 wines, known as 'The Twelve Apostles' and 'Les Gouttes de Dieu' that his father described in his will. He has a competitor by the name of Toomine Issei - an acclaimed young wine critic who just happens to be his father's adopted son. Shizuku has never drunk, nor had any previous knowledge of wine, but with strong senses he submerges himself in the world of wine to solve the mysteries of the 13 wines.
