Drawing on her own medical experience as well as fifteen years of interviews with doctors, patients, researchers, and public health experts, O'Rourke's incisive new work speaks to an urgent subject: the epidemic scale of autoimmune disease in America (even greater with the advent of 'Long Covid') and where we go from here. O'Rourke reveals crucial, subtle complexities about the American struggle with chronic illness and autoimmune conditions, and offers new reasons for hope, as well as a new framework for thinking about infectious disease and autoimmune response going forward.