Joe Keen and Ana Urbanek have been a couple for a long time, with all the requisite lulls and temptations, yet they remain unmarried and without children or a mortgage, as their Midwestern values (and parents) seem to require. Now on the cusp of forty, they are both working at jobs that they're not even sure they believe in anymore, but with significantly varying returns. The Narcissism of Small Differences is the story of Joe and Ana's life together, their relationship, their tribes, their work and passions, and their comic quest for a life that is their own and no one else's.