The politics and terrors of biotech, human engineering, and brain science are given startling fictional form in a selection of short stories with Michael Blumlein's signature mix of fantasy, science fiction, horror, and wicked humour. The title piece, 'Thoreau's Microscope,' is a stunning mix of hypothesis and history, in which the author inhabits Thoreau's last days to explore the politics of impersonal science and personal liberation - a journey as illuminating as it is disturbing. On a lighter note, 'Fidelity' coolly deconstructs adultery with the help of an exuberant tumour, a guinea pig, and a swimsuit. 'Y(ou)r Q(ua)ntifi(e)d S(el)f' will reset your Fitbit and your personal goals as well. 'Paul and Me' is a legendary love story writ extra-large; and in 'Know How, Can Do' a female Frankenstein brings romance to life in the cold light of the lab.